Pablo NAVARRO Lab: G5 Institut Pasteur

"I would see an additional reason for having confidence in the development of our discipline which, transcending its original domain, the chemistry of heredity, today is oriented toward the analysis of the more complex biological phenomena: the development of higher organisms and the operation of their networks of functional coordinations."


Jacques Monod, Nobel Lecture, December 11, 1965

Immunofluorescence of Nanog (red) and H3K36me3 (green) of a single DAPI-stained ES cell.
Immunofluorescence of Nanog (red) and H3K36me3 (green) of a single DAPI-stained ES cell.

WE study the epigenetic processes governing the biology of mouse Embryonic Stem (ES) cells with the broad goals of:

(i) increasing our knowledge on fundamental aspects of gene regulation in mammalian systems.

(ii) obtaining a comprehensive view of the molecular principles underpinning the properties of ES cells (self-renewal and pluripotency). 

Providing a new level of knowledge on these aspects should help us understand how epigenetic mechanisms and gene regulatory networks influence cellular-decision making processes.


  1. How chromatin modifications contribute to cell-to-cell variability and gene expression heterogeneity within the undifferentiated ES cell population.
  2. How the regulatory continuity between cell generations is controlled and influenced by mitosis, a dramatic event regarding Transcription Factor-mediated control. 
  3. How non-coding RNAs contribute to the activity of the pluripotency network and to the nuclear organisation of the mouse ES cell genome.

H3K4me3 (blue) and H3K27me3 (red) profiles across a 300kb-long genomic region
Paris, FRANCE
Paris, FRANCE

INSTITUT PASTEUR

Department of Developmental and Stem Cell Biology

CNRS URA2578

Genetic, molecular and cellular basis of development

ANR -Investissements d'avenir- REVIVE LabEx

How to find us?

Created by Pablo Navarro