Pablo NAVARRO Lab: G5 Institut Pasteur

Immunofluorescence of Nanog (red) and H3K36me3 (green) of a single DAPI-stained ES cell.
Immunofluorescence of Nanog (red) and H3K36me3 (green) of a single DAPI-stained ES cell.

WE study the epigenetic processes governing the biology of mouse Embryonic Stem (ES) cells with the broad goals of:

(i) increasing our knowledge on fundamental aspects of gene regulation in mammalian systems.

(ii) obtaining a comprehensive view of the molecular principles underpinning the properties of ES cells (self-renewal and pluripotency). 

Providing a new level of knowledge on these aspects should help us understand how epigenetic mechanisms and gene regulatory networks influence cellular-decision making processes.


  1. How chromatin modifications contribute to cell-to-cell variability and gene expression heterogeneity within the undifferentiated ES cell population.
  2. How the regulatory continuity between cell generations is controlled and influenced by mitosis, a dramatic event regarding Transcription Factor-mediated control. 
  3. How non-coding RNAs contribute to the activity of the pluripotency network and to the nuclear organisation of the mouse ES cell genome.

H3K4me3 (blue) and H3K27me3 (red) profiles across a 300kb-long genomic region
Paris, FRANCE
Paris, FRANCE

INSTITUT PASTEUR

Department of Developmental and Stem Cell Biology

CNRS URA2578

Genetic, molecular and cellular basis of development

ANR -Investissements d'avenir- REVIVE LabEx

How to find us?

Created by Pablo Navarro