Pablo NAVARRO Lab: G5 Institut Pasteur

"I would see an additional reason for having confidence in the development of our discipline which, transcending its original domain, the chemistry of heredity, today is oriented toward the analysis of the more complex biological phenomena: the development of higher organisms and the operation of their networks of functional coordinations."

Jacques Monod, Nobel Lecture, December 11, 1965

single-molecule analysis of Nanog: red, pre-mRNA; green, mRNA

WE study the gene regulatory processes governing the biology of mouse Embryonic Stem (ES) cells with the broad goals of:

(i) increasing our knowledge on fundamental aspects of epigenetic gene regulation in mammalian systems.

(ii) obtaining a comprehensive view of the molecular principles underpinning the properties of ES cells (self-renewal and pluripotency). 

Providing a new level of knowledge on these aspects should help us understand how epigenetic mechanisms and gene regulatory networks influence cellular-decision making processes.

  1. How chromatin modifications contribute to cell-to-cell variability and gene expression heterogeneity within the undifferentiated ES cell population.
  2. How the regulatory continuity between cell generations is controlled and influenced by mitosis, a dramatic event regarding Transcription Factor-mediated control. 
  3. How non-coding RNAs contribute to the activity of the pluripotency network and to the nuclear organisation of the mouse ES cell genome.


Department of Developmental and Stem Cell Biology


Genetic, molecular and cellular basis of development

ANR -Investissements d'avenir- REVIVE LabEx

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Created by Pablo Navarro