Pablo NAVARRO Lab - Institut Pasteur

"I would see an additional reason for having confidence in the development of our discipline which, transcending its original domain, the chemistry of heredity, today is oriented toward the analysis of the more complex biological phenomena: the development of higher organisms and the operation of their networks of functional coordinations."


Jacques Monod, Nobel Lecture, December 11, 1965

single-molecule analysis of Nanog: red, pre-mRNA; green, mRNA

WE study the gene regulatory processes governing the biology of mouse Embryonic Stem (ES) cells with the broad goals of:

(i) increasing our knowledge on fundamental aspects of epigenetic gene regulation in mammalian systems.

(ii) obtaining a comprehensive view of the molecular principles underpinning the properties of ES cells (self-renewal and pluripotency). 

Providing a new level of knowledge on these aspects should help us understand how epigenetic mechanisms and gene regulatory networks influence cellular-decision making processes.


  1. How signaling, chromatin states and TFs orchestrate cell-fate decisions.
  2. How the regulatory continuity between cell generations is mediated by TFs. 
  3. How non-coding RNAs contribute to self-renewal and pluripotency.

INSTITUT PASTEUR

Department of Developmental and Stem Cell Biology

CNRS UMR3738

Genetic, molecular and cellular basis of development

ANR -Investissements d'avenir- REVIVE LabEx

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Created by Pablo Navarro